Mastering Skin Longevity

For 80 years, The Estée Lauder Companies has advanced skin science and innovation, including more than two decades of pioneering research into skin longevity.

Building on that legacy, in 2026 we unveiled Mastering Skin Longevity, a breakthrough scientific innovation platform designed to advance the next era of skin science and transformative product innovation.

Moving beyond the study of individual Hallmarks of Aging, Mastering Skin Longevity focuses further upstream on the Master Regulators of Skin Longevity, interconnected biological pathways and proteins that influence multiple hallmarks at once. By deepening our understanding of these systems and how they help support skin’s ability to repair, adapt and regenerate, Mastering Skin Longevity helps guide discovery across ingredients, technologies, formulations and future product innovation.

The Skin Longevity Clock

The Skin Longevity Clock brings Mastering Skin Longevity to life through a distinctive visual representation of the platform.

Inspired by the precision and interconnected mechanisms of a fine timepiece, the Clock illustrates how the Master Regulators work together to influence multiple Hallmarks of Aging, shaping processes associated with skin repair, adaptation, renewal and resilience over time.

Master Regulators: The Next Frontier in Skin Longevity

The Hallmarks of Aging help us understand the molecular and cellular changes associated with how skin ages over time. The Master Regulators take us further upstream, helping us investigate the interconnected biological systems that influence multiple hallmarks at once.

Today, scientists across The Estée Lauder Companies’ Longevity Labs in Melville and Shanghai are advancing research into Master Regulators including:

SIRTUINS


Influence cellular longevity and stress response.

AMPK


Regulates cellular energy, homeostasis, and metabolic adaptation.

mTOR


Supports cellular renewal, regeneration, and repair signaling.

Studying these systems together creates a more integrated foundation for discovery and new opportunities across ingredients, technologies, formulations, and products.

Longevity Science by the Numbers 

80 Years of Breakthrough Skin Science

80 Years of Breakthrough Skin Science


A legacy of innovation and discovery, powered by global innovation centers and scientific expertise advancing next-generation skin care

20+ Years Pioneering Skin Longevity Research

20+ Years Pioneering Skin Longevity Research


We are the early leader decoding the biology of skin aging with Estée Lauder’s in-depth research of sirtuins, or “longevity proteins,” and their role in skin vitality and visible age reversal

50+ Years of Bio-Fermentation & Bio-Energetics Mastery

50+ Years of Bio-Fermentation & Bio-Energetics Mastery


Half a century of expertise rooted in La Mer’s Miracle Broth™, shaping our leadership in cellular energy and regenerative science

44 Patents Powering the Future of Longevity

44 Patents Powering the Future of Longevity


Breakthrough intellectual property spanning molecular pathways, rejuvenation technologies, and advanced delivery systems

60+ Scientific Publications

60+cScientificcPublications


A steady pipeline of research contributions that shape our understanding of skin longevity, backed by leading experts.

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